Patterns of Copy-number Evolution
Cancer cells continually evolve through mutations that reshape their genome, facilitating their growth over healthy cells. Copy-number alterations involve changes in the physical number of copies of specific genomic regions, encompassing both gains and losses. Our research seeks to infer individual copy-number altering events from patient DNA data, reconstructing the evolutionary trajectory of these alterations and identifying recurring patterns. This investigation aims to elucidate how diverse mutation processes collaborate to form intricate copy-number patterns and their implications for patient outcomes.
Fellow
Doctoral Researcher