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Prof. Dr. Roland Schwarz

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University of Cologne

Prof. Dr. Roland Schwarz

Fellow

Fellow | BIFOLD

Principle Investigator | Professor for Computational Cancer Biology, Center for Integrative Oncology (CIO), Cancer Research Center
Cologne Essen (CCCE), University of Cologne, Germany

2016 Prize of the Berlin Brandenburg Academy of Science for Cancer Research
2010 – 2016 Junior Research Fellowship, Wolfson College, University of Cambridge
2013 Finalist EMBL Outstanding Postdoc Award

  • Cancer Genomics
  • Regulatory Genomics
  • Data Science
  • Machine Learning
  • Artificial Intelligence
  • Big Data

Philipp Keyl, Julius Keyl, Andreas Mock, Gabriel Dernbach, Liliana H Mochmann, Niklas Kiermeyer, Philipp Jurmeister, Michael Bockmayr, Roland F Schwarz, Grégoire Montavon, Klaus-Robert Müller, Frederick Klauschen

Neural interaction explainable AI predicts drug response across cancers

September 03, 2025
https://doi.org/10.1093/narcan/zcaf029

Andrew McPherson, Ignacio Vázquez-García, Matthew A. Myers, Duaa H. Al-Rawi, Matthew Zatzman, Adam C. Weiner, Samuel Freeman, Neeman Mohibullah, Gryte Satas, Marc J. Williams, Nicholas Ceglia, Danguolė Norkūnaitė, Allen W. Zhang, Jun Li, Jamie L. P. Lim, Michelle Wu, Seongmin Choi, Eliyahu Havasov, Diljot Grewal, Hongyu Shi, Minsoo Kim, Roland F. Schwarz, Tom Kaufmann, Khanh Ngoc Dinh, Florian Uhlitz, Julie Tran, Yushi Wu, Ruchi Patel, Satish Ramakrishnan, DooA Kim, Justin Clarke, Hunter Green, Emily Ali, Melody DiBona, Nancy Varice, Ritika Kundra, Vance Broach, Ginger J. Gardner, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Sarah H. Kim, Rachel N. Grisham, Ying L. Liu, Agnes Viale, Nicole Rusk, Yulia Lakhman, Lora H. Ellenson, Simon Tavaré, Samuel Aparicio, Dennis S. Chi, Carol Aghajanian, Nadeem R. Abu-Rustum, Claire F. Friedman, Dmitriy Zamarin, Britta Weigelt, Samuel F. Bakhoum & Sohrab P. Shah

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

July 15, 2025
https://doi.org/10.1038/s41586-025-09240-3

Ibai Irastorza-Azcarate, Alexander Kukalev, Rieke Kempfer, Christoph J Thieme, Guido Mastrobuoni, Julia Markowski, Gesa Loof, Thomas M Sparks, Emily Brookes, Kedar Nath Natarajan, Stephan Sauer, Amanda G Fisher, Mario Nicodemi, Bing Ren, Roland F Schwarz, Stefan Kempa, Ana Pombo

Extensive folding variability between homologous chromosomes in mammalian cells

May 06, 2025
https://doi.org/10.1038/s44320-025-00107-3

Maise Al Bakir, James L. Reading, Samuel Gamble, Rachel Rosenthal, Imran Uddin, Andrew Rowan, Joanna Przewrocka, Amber Rogers, Yien Ning Sophia Wong, Amalie K. Bentzen, Selvaraju Veeriah, Sophia Ward, Aaron T. Garnett, Paula Kalavakur, Carlos Martínez-Ruiz, Clare Puttick, Ariana Huebner, Daniel E. Cook, David A. Moore, Chris Abbosh, Crispin T. Hiley, Cristina Naceur-Lombardelli, Thomas B. K. Watkins, Marina Petkovic, Roland F. Schwarz, Felipe Gálvez-Cancino, Kevin Litchfield, Peter Meldgaard, Boe Sandahl Sorensen, Line Bille Madsen, Dirk Jäger, Martin D. Forster, Tobias Arkenau, Clara Domingo-Vila, Timothy I. M. Tree, Mohammad Kadivar, Sine Reker Hadrup, Benny Chain, Sergio A. Quezada, Nicholas McGranahan, Charles Swanton

Clonal driver neoantigen loss under EGFR TKI and immune selection pressures

February 19, 2025
https://www.nature.com/articles/s41586-025-08586-y#Ack1

Maja C. Stöber, Rocío Chamorro González, Lotte Brückner, Thomas Conrad, Nadine Wittstruck, Annabell Szymansky, Angelika Eggert, Johannes H. Schulte, Richard P. Koche, Anton G. Henssen, Roland F. Schwarz, Kerstin Haase

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity

September 24, 2024
https://doi.org/10.1016/j.celrep.2024.114711

BIFOLD Update| Aug 06, 2020

An overview of the current state of research in BIFOLD

Since the official announcement of the Berlin Institute for the Foundations of Learning and Data in January 2020, BIFOLD researchers achieved a wide array of advancements in the domains of Machine Learning and Big Data Management as well as in a variety of application areas by developing new Systems and creating impactfull publications. The following summary provides an overview of recent research activities and successes.

Machine Learning| Jun 04, 2020

Cloud computing contributes to cancer research

PCAWG, the largest cancer research consortium in the world, has set itself the task of improving our understanding of genetic mutations in tumors. A new study by the international research group, to which researchers in BIFOLD senior researcher Dr. Roland Schwarz’ group at the Max Delbrück Center for Molecular Medicine (MDC) substantially contributed, is now being published in the journal Nature.